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Salix Injectable (50 mg/ml) 50 ml vial Description
Salix® Injectable is diuretic that possesses a wide range of therapeutic uses. It promotes rapid eradication of extracellular fluid that has been retained abnormally. The reason behind using this medication as a diuretic treatment are based on the edema-producing pathology.
What is Salix Injectable (50 mg/ml) 50 ml vial?
Salix Injectable (50 mg/ml) 50 ml vial is an effective diuretic for dogs, cats & horses. Salix has a wide therapeutic range and is often used to treat edema (pulmonary congestion, ascites) associated with carida insufficiency and acute noninflammatory tissue edema. In cattle Salix is used to treat physiological parturient edema of the mammary gland associated structures.
Which animals/pets is Salix Injectable (50 mg/ml) 50 ml vial for?
For use in cattle, horses, cats, and dogs.
Salix Injectable (50 mg/ml) 50 ml vial uses
Features of Salix®:
- Fast-acting with a short comparative duration
- High therapeutic index
- Low inherent toxicity
- Highly effective
- Saluretic and diuretic for fast edema relief
What does Salix Injectable (50 mg/ml) 50 ml vial do?
The therapeutic effectiveness of Salix® comes from the action of the unaltered, intact molecule within the nephron, which inhibits sodium reabsorption in the ascending Henle loop and the distal and proximal tubule.
Salix Injectable (50 mg/ml) 50 ml vial side effects
Potential side effects include:
- Hearing loss (particularly common in cats in cases where large quantities were used in crisis management)
- Increased levels of blood sugar (not an issue in most animals; however, another diuretic might be better suited for patients with diabetes)
- Increased urination
- Increased thirst
Salix Injectable (50 mg/ml) 50 ml vial ingredients
Furosemide
Salix Injectable (50 mg/ml) 50 ml vial overdose: What to do?
Immediately contact your closest emergency animal hospital.
What to know before using Salix Injectable (50 mg/ml) 50 ml vial
- Use caution when administering to animals on potassium-depleting steroids.
- Excessive potassium loss in animals on glycosides or digitalis can cause digitalis toxicity.
- This medication is an incredibly effective diuretic. Like any diuretic, it can cause excessive diuresis if administered excessively. This can lead to dehydration, imbalance of electrolytes, and reduced plasma volume, which increases the risk of embolism, thrombosis, and circulatory collapse. Because of these concerns, animals should always be observed for early fluid depletion and electrolyte imbalance symptoms. If noted, corrective measures should be immediately initiated.
- Potassium deficiencies should be corrected with supplementation.
- Exercise caution when administering potassium tablets coated in enteric.
How is Salix Injectable (50 mg/ml) 50 ml vial sold?
50 mg/ml, 50 ml vial
Manufacturer
Merck Animal Health.
Tips for using Salix Injectable (50 mg/ml) 50 ml vial
Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids.
It is important to correct potassium deficiency with dietary supplementation. Caution should be exercised in prescribing enteric-coated potassium tablets.
Overview
The usual dosage of Salix® is 1 to 2 mg/lb. body weight (approximately 2.5 to 5 mg/kg). The lower dosage is suggested for cats. Administer once or twice daily at 6 to 8 hour intervals either orally, intravenously, or intramuscularly. A prompt diuresis usually ensues from the initial treatment. Diuresis may be initiated by the parenteral administration of Salix® Injection and then maintained by oral administration.
The dosage should be adjusted to the individual's response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1 mg per pound body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dosage schedule, i.e., every other day or 2 to 4 consecutive days weekly.
Diuretic therapy should be discontinued after reduction of the edema, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. For long-term treatment, the dose can generally be lowered after the edema has once been reduced. Re-examination and consultations with client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN, CO2 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn.
DOSAGE: ORAL
DOG AND CAT - One-half to one 50 mg scored tablet per 25 pounds body weight.
One 12.5 mg tablet per 5 to 10 pounds body weight.
Administer once or twice daily, permitting a 6 to 8 hour interval between treatments. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 mg per pound body weight as recommended in preceding paragraphs, "Dosage and Administration".
PARENTERAL:
DOG AND CAT - Administer intramuscularly or intravenously 1/4 to 1/2 mL per 10 pounds body weight.
Administer once or twice daily, permitting a 6 to 8 hour interval between treatments. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 mg per pound body weight as recommended in preceding paragraphs, "Dosage and Administration".
HORSE - The individual dose is 250 to 500 mg (5 to 10 mL) administered intramuscularly or intravenously once or twice daily at 6 to 8 hour intervals until desired results are achieved. The veterinarian should evaluate the degree of edema present and adjust dosage schedule accordingly. Do not use in horses intended for human consumption.
CATTLE - The individual dose administered intramuscularly or intravenously is 500 mg (10 mL) once daily or 250 mg (5 mL) twice daily at 12 hour intervals. Treatment not to exceed 48 hours postparturition.
Milk taken from animals during treatment and for 48 hours (four milkings) after the last treatment must not be used for food. Cattle must not be slaughtered for food within 48 hours following last treatment.
Main Ingredients
Salix® (furosemide) Injection 5% Each mL contains: 50 mg furosemide as a diethanolamine salt preserved and stabilized with myristyl-gamma-picolinium chloride 0.02%, EDTA sodium 0.1%, sodium sulfite 0.1% with sodium chloride 0.2% in distilled water, pH adjusted with sodium hydroxide.
